反应详情

A mixture of 2,2,6,6-tetramethyl-4-bromo-3,5-heptanedione (70 g) and urea (77 g) in DMF (500 mL) is heated at 110°-120° C. overnight. The reaction mixture is cooled and poured into ice water (1500 mL) and the resulting precipitate is collected by filtration and air dried. The solid is rinsed with hexane (1000 mL) and then with isopropyl ether (200 mL) and dried under vacuum overnight to give 1-[2-amino-4-(1,1-dimethylethyl)-5-oxazolyl]-2,2 dimethyl-1-propanone (25.5 g, 42%); mp 248°-250° C.

1. temperatureis heated at 110°-120° C. overnight
2. temperatureThe reaction mixture is cooled
3. filtrationthe resulting precipitate is collected by filtration and air
4. customdried
5. washThe solid is rinsed with hexane (1000 mL)
6. dry with materialwith isopropyl ether (200 mL) and dried under vacuum overnight