反应详情

3-Methyl-6-nitroindazole (5.31 g), 6.93 g of 2-bromo-6-methoxybenzoic acid, 4.71 g of potassium carbonate and 0.218 g of copper (II) oxide were stirred in 60 ml of nitrobenzene at 180° C. for 50 minutes. After cooling, 300 ml of water was added to the reaction mixture, and the insoluble substance was removed by filtration. The resulting solution was washed with chloroform. The aqueous layer was decolored with active charcoal and filtered, and 40 ml of 1 N hydrochloric acid aqueous solution was added to the filtrate. The crystals precipitated were separated by filtration and dried under reduced pressure to obtain 7.45 g (75.9%) of 1-(2-carboxy-3-methoxyphenyl)-3-methyl-6-nitroindazole.

1. temperatureAfter cooling
2. customthe insoluble substance was removed by filtration
3. washThe resulting solution was washed with chloroform
4. filtrationfiltered
5. addition40 ml of 1 N hydrochloric acid aqueous solution was added to the filtrate
6. customThe crystals precipitated
7. customwere separated by filtration
8. customdried under reduced pressure