Guaiacol → HCID 67791299, compound

HRID 1588102Notes

Reaction equation

HRID 1588102 reaction equation
[OH-].[CH3:2][N+:3]([CH3:6])([CH3:5])[CH3:4].CO.[C:9]1([O:16][CH3:17])[C:10](=[CH:12][CH:13]=[CH:14][CH:15]=1)[OH:11]>CO>[CH3:2][N+:3]([CH3:6])([CH3:5])[CH3:4].[CH3:17][O:16][C:9]1[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=1[O-:11].[CH:10]([OH:11])([CH3:12])[CH3:9]

Participants

4

Reactant 2

HCID 460GuaiacolHCID 19757443HCID 19757443, compound

Product 1

HCID 67791299HCID 67791299, compoundYield 200%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 5.20 ml of a commercially available 10% tetramethylammonium hydroxide-methanol solution (manufactured by TOKYO KASEI; 5.05 mmole equivalents) was added 0.6264 g of guaiacol (5.05 mmoles), and methanol was removed under reduced pressure. To the residue was added 10 ml of isopropanol, and the alcohol was removed under reduced pressure again. Finally 5 ml of isopropanol was added to obtain about 7 ml of a tetramethylammonium-2-methoxyphenolate-isopropanol solution (containing 5.05 mmoles of guaiacol).

Workup

  1. customwas removed under reduced pressure
  2. additionTo the residue was added 10 ml of isopropanol
  3. customthe alcohol was removed under reduced pressure again
  4. additionFinally 5 ml of isopropanol was added

Sources & evidence

ORD record
ord-3b0a4ab50fd444f88ef94a30cc98b25c
Source dataset
uspto-grants-1993_06
Patent number
US05220079

Reaction notes

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