HRID1588187

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21

HCID76845

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy-

C20H13NO5

HCID160435

Methanediimine

CH2N2

PRODUCTS

生成物

结构：O=C(O)c1ccccc1-c1c2ccc(=O)cc-2oc2cc(O)ccc12

HCID3383

2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid

C20H12O5

HCID76845

Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 5-amino-3',6'-dihydroxy-

C20H13NO5

PROCEDURE

实验过程

Alternatively, the product from step 1 can be reacted in the presence of carbodiimide with fluoresceinamine (FAM) (Reaction C) to provide 5-[2',3'-dideoxyinosin-5'-yl)-succinamido]-fluorescein (ddI-5'-S:FAM). An additional alternative is to react the product from step 2 with 5-[N'-(2-aminoethyl)-thioureido]fluorescein (fluoresceinthiocarbamylethylenediamine) (FTED) (Reaction D) to provide the tracer 5-[2-(2',3'-dideoxyinosin-5'-yl-succinamido)-ethylthiocarbamyl -fluorescein (ddI-5.-S:FTED).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-89b67904a1474a93abc56a053506daea
来源数据集: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05221611
来源说明: uspto-grants-1993_06

反应 SMILES

N=C=N.[CH:4]1[C:9]([NH2:10])=[CH:8][C:7]2[C:11]([O:13][C:14]3([C:24]4[CH:25]=[CH:26][C:27]([OH:29])=[CH:28][C:23]=4[O:22][C:16]4[CH:17]=[C:18]([OH:21])[CH:19]=[CH:20][C:15]3=4)[C:6]=2[CH:5]=1)=[O:12]>>[CH:4]1[CH:9]=[CH:8][C:7]([C:11]([OH:13])=[O:12])=[C:6]([C:14]2[C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][C:16]=3[O:22][C:23]3[C:24]=2[CH:25]=[CH:26][C:27]([CH:28]=3)=[O:29])[CH:5]=1.[CH:4]1[C:9]([NH2:10])=[CH:8][C:7]2[C:11]([O:13][C:14]3([C:24]4[CH:25]=[CH:26][C:27]([OH:29])=[CH:28][C:23]=4[O:22][C:16]4[CH:17]=[C:18]([OH:21])[CH:19]=[CH:20][C:15]3=4)[C:6]=2[CH:5]=1)=[O:12]