反应详情

After mixing 3.7 g of 2,4-dinitrofluorobenzene, 20 ml of dimethylformamide, 2.9 g of 5-t-butyl-3-hydroxyisoxazole, and 2.8 g of potassium carbonate, the reaction was performed for 30 minutes at 80° C. and after cooling the reaction mixture, the product formed was extracted with a mixture of diethyl ether and ethyl acetate. The solvent was distilled off from the extract under reduced pressure and the residue obtained was crystallized from a mixture of diethyl ether and ethyl acetate to provide 1.9 g of the desired compound with a yield of 30.9%. The melting point thereof was 167° C. to 168° C.

1. temperatureafter cooling the reaction mixture
2. customthe product formed
3. extractionwas extracted with a mixture of diethyl ether and ethyl acetate
4. distillationThe solvent was distilled off from the
5. extractionextract under reduced pressure
6. customthe residue obtained
7. customwas crystallized from a mixture of diethyl ether and ethyl acetate