Pyridine → 1,8-Diazabicyclo(5.4.0)undec-7-ene

HRID 1588500Notes

Reaction equation

HRID 1588500 reaction equation
ClC([O-])=O.[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C1COCC1>[CH2:8]1[CH2:9][CH2:10][N:5]2[C:10](=[N:5][CH2:6][CH2:7][CH2:8]2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 1049PyridineHCID 21226386Carbonochloridate

Product 1

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compounds of Formula (I) wherein R1 is --SO2NHCO2R23 may be prepared by reacting an appropriate chloroformate with the sulfonamide (28) in pyridine or in the presence of DBU in THF to afford the desired compound (30), as outlined in Scheme 10. ##STR83##

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-a107208fb88f4743a44063d8519b825b
Source dataset
uspto-grants-1993_06
Patent number
US05223501

Reaction notes

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