Acetic Acid → Methyl Picolinimidate

HRID 1588503Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1588503
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].C[O-].[Na+].[C:12](O)(=[O:14])C>CO>[N:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:1](=[NH:2])[O:14][CH3:12]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 7522Pyridine-2-carbonitrileHCID 10942334Sodium Methoxide

Produkt 1

HCID 152260Methyl Picolinimidate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-cyanopyridine (10.0 g, 96.1 mmol) was dissolved in methanol (50 ml). Sodium methoxide (0.26 g, 4.8 mmol) was added to the solution, and reaction was conducted for 6 hours at room temperature. After the reaction was completed, acetic acid (0.32 g, 5.3 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (50 ml) was added to the concentrated residue, and diethyl ether insoluble products were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 2-pyridinecarboximidate as a pale yellow oil in a yield of 7.5 g.

Aufarbeitung

  1. concentrationthe solution was concentrated under reduced pressure
  2. additionDiethyl ether (50 ml) was added to the concentrated residue, and diethyl ether insoluble products
  3. customwere removed by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-73050a0ec1544cdfa19124f07073cdc7
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05223508

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