Ethylamine → HCID 8625259, compound

HRID 1588643Notes

Reaction equation

HRID 1588643 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:13]=[C:14]=[S:15])[CH2:3][CH2:2]1.[CH2:16]([NH2:18])[CH3:17].Cl.C(N)C>C[O-].[Na+]>[CH2:16]([NH:18][C:14]([NH:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[N:4]1[CH2:3][CH2:2][O:1][CH2:6][CH2:5]1)=[S:15])[CH3:17]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 11198Ethylamine hydrochlorideHCID 50854564-(2-isothiocyanatophenyl)morpholine

Product 1

HCID 8625259HCID 8625259, compound

Reagents, catalysts & solvents 1

HCID 10942334Sodium MethoxideSolvent

Procedure

Reaction of 2-morpholinophenyl isothiocyanate (3.3 g) with ethylamine generated from ethylamine hydrochloride (12.18 g) and sodium methoxide [generated from sodium (3.5 g) and methanol (100 ml)] gave 1-ethyl-3-(2-morpholinophenyl)thiourea (m.p. 118°-120° C.) which was recrystallised from a 1:1 mixture of ethylacetate and hexane.

Sources & evidence

ORD record
ord-34a640c0a7534c07bd35173916a62bc6
Source dataset
uspto-grants-1993_06
Patent number
US05223498

Reaction notes

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