反应详情

温度

0 °C

Place lithium hexamethyldisilazane (20 mL of a 1 M solution in tetrahydrofuran, 20 mmol) under an argon atmosphere and cool to 0° C. Add, by dropwise addition, trimethylsilylacetylene (2.83 mL, 20 mmol) and stir for 1 hour at 0° C. Add benzaldehyde (2.03 mL, 20 mmol) in tetrahydrofuran (10 mL). Allow to warm to room temperature and stir for 1 hour. Pour the mixture into ethyl ether and water, separate the organic phase and evaporate the solvent in vacuo. Filter the oil through silica gel (20% ethyl acetate/hexane) and evaporate the solvent in vacuo to yield 4.09 g of the title compound.

1. temperatureAllow to warm to room temperature
2. stirringstir for 1 hour
3. customseparate the organic phase
4. customevaporate the solvent in vacuo
5. filtrationFilter the oil through silica gel (20% ethyl acetate/hexane)
6. customevaporate the solvent in vacuo