4-(3-Aminophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide → 4-(3-Aminophenyl)-2-piperazinecarboxamide

HRID 1588993Notes

Reaction equation

HRID 1588993 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][N:11](CC3C=CC=CC=3)[CH:10]([C:21]([NH2:23])=[O:22])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1>[OH-].[OH-].[Pd+2].CO>[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH:10]([C:21]([NH2:23])=[O:22])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 149988144-(3-Aminophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

Product 1

HCID 149988184-(3-Aminophenyl)-2-piperazinecarboxamide

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

To methanol add 4-(3-aminophenyl)-1-(phenylmethyl)-2-piperazinecarboxamide and Pd(OH)2. Place the reaction on a Parr hydrogenator at 50 psi of H2 and shake. Monitor the progress of the reaction by thin-layer chromatography. Upon completion of the reaction, remove the catalyst by suction filtration through celite. Remove solvent in vacuo to obtain the title compound.

Workup

  1. customthe reaction on a Parr hydrogenator at 50 psi of H2 and shake
  2. customMonitor the progress of the reaction by thin-layer chromatography
  3. customUpon completion of the reaction
  4. customremove the catalyst
  5. filtrationby suction filtration through celite

Sources & evidence

ORD record
ord-21176ba0ae824e138dc70f5be1060c36
Source dataset
uspto-grants-1993_06
Patent number
US05223623

Reaction notes

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