Ethylene carbonate → 2-(4-(1-Methylethenyl)phenoxy)ethanol

HRID 1589119ノート

反応式

HRID 1589119 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([CH3:3])=[CH2:2].C1(=O)O[CH2:14][CH2:13][O:12]1.O.O.[F-].[K+]>CN(C)C=O>[CH3:2][C:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:14][CH2:13][OH:12])=[CH:6][CH:5]=1)=[CH2:3]

参加物

5

反応物 3

HCID 7303Ethylene carbonateHCID 584247p-IsopropenylphenolHCID 23708904Potassium fluoride dihydrate

生成物 1

HCID 137506132-(4-(1-Methylethenyl)phenoxy)ethanol収率 69%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
150 °C

実験手順

A mixture of 20 g p-isopropenylphenol, 1.1 equivalents ethylene carbonate, 0.02 equivalent potassium fluoride dihydrate, and 200 ml N,N-dimethylformamide (DMF) was heated at about 150° C. for about 1.5 hours. After removal of DMF under reduced pressure, the crude product was distilled. 2-(4-(1-Methylethenyl)phenoxy)ethanol, bp 143° C./7 torr, was obtained as a white solid in 69% yield.

後処理

  1. customAfter removal of DMF under reduced pressure
  2. distillationthe crude product was distilled

出典と根拠

ORDレコード
ord-1f0c4176d92445d0a3f1eda6fed5ce78
出典データセット
uspto-grants-1986_02
特許番号
US04568497

反応ノート

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