Hydrochloric Acid → HCID 20248334, compound

HRID 1589192Notes

Reaction equation

HRID 1589192 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:22])[N:7]([CH2:14][CH2:15][CH2:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)[C:8]2=[O:13])([O-])=O.Cl>[Pd].C(O)C>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:22])[N:7]([CH2:14][CH2:15][CH2:16][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)[C:8]2=[O:13]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 13588983HCID 13588983, compound

Product 1

HCID 20248334HCID 20248334, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 0.1 mole of 4-nitro-2-[3-(1H-imidazol-1-yl)propyl]-1H-isoindole-1,3(2H)-dione, 200 ml. of ethanol, 0.1 mole of 12N hydrochloric acid and 1.0 g. of Pd/C catalyst was reduced in a Parr hydrogenator under an initial H2 pressure of 45 pounds per square inch pressure. The catalyst was filtered off and the solvent was removed to obtain the desired compound as the hydrochloride salt.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-fe240a080ef84bc2a1a1b095ac9f01c2
Source dataset
uspto-grants-1986_02
Patent number
US04568687

Reaction notes

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