Pyrrolidine → 2-Methoxy-5-(pyrrolidine-1-sulfonyl)-benzoic acid

HRID 1589355Notes

Reaction equation

HRID 1589355 reaction equation
Cl[S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:14][CH3:15])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1>O>[N:16]1([S:2]([C:5]2[CH:6]=[CH:7][C:8]([O:14][CH3:15])=[C:9]([CH:13]=2)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3])[CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 1040075-Chlorosulphonyl-2-anisic acid

Product 1

HCID 7373482-Methoxy-5-(pyrrolidine-1-sulfonyl)-benzoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Chlorosulphonyl-2-methoxybenzoic acid (4.9 g) was added to a solution of pyrrolidine (10 g) in water (150 ml). The solution was stirred for 6 hours, filtered and acidified with dilute hydrochloric acid to yield the title compound as colourless microcrystals (5.27 g; 84%).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-0000e4af13c64b479b730aa29731b5e7
Source dataset
uspto-grants-1986_02
Patent number
US04569940

Reaction notes

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