Hydrochloric Acid → HCID 14623255, compound

The starting material may be prepared as follows. A mixture of 1,2,4-triazole (5 g.) and 4-methyl-1,3-dioxolan-2-one was heated at 150° for 18 hours. Concentrated aqueous hydrochloric acid (8 ml.) was added dropwise to the ice-cooled mixture and the mixture was washed with chloroform. The aqueous phase was neutralised with aqueous potassium carbonate solution and extracted with chloroform, and the chloroform extract was dried and evaporated to dryness to give 1-(2-hydroxypropyl)-1,2,4-triazole (7.8 g.) which was characterised as the hydrogen oxalate, m.p. 110°-112° (after crystallisation from EtOH).

1. customThe starting material may be prepared
2. temperaturewas heated at 150° for 18 hours
3. temperaturecooled mixture
4. washthe mixture was washed with chloroform
5. extractionextracted with chloroform
6. extractionthe chloroform extract
7. customwas dried
8. customevaporated to dryness

ORD record

ord-51d4f9a61bfc464285d249c2bf140239

Source dataset

uspto-grants-1986_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04570000