反应详情

温度

100 °C

10.00 g (58.8 mM) of methyl 3-fluoro-4-hydroxybenzoate and 17.5 ml of 80%-hydrazine hydrate were mixed and stirred for 1 hour and 20 minutes at 100° C., followed by cooling to room temperature. The resultant mixture was poured into 150 ml of iced water and 16.8 ml of concentrated hydrochloric acid was added thereto (pH=about 8), followed by addition of common salt and stirring at room temperature to precipitate a crystal. The crystal was recovered by filtration and stirred in methanol at room temperature. The resultant crystal was recovered from the above mixture by filtration to obtain 9.26 g of 3-fluoro-4-hydroxybenzohydrazide (Yield: 92.6%).

1. temperatureby cooling to room temperature
2. additionwas added
3. addition(pH=about 8), followed by addition of common salt
4. stirringstirring at room temperature
5. customto precipitate a crystal
6. filtrationThe crystal was recovered by filtration
7. stirringstirred in methanol at room temperature
8. filtrationThe resultant crystal was recovered from the above mixture by filtration