Methyl trifluoroacetate → HCID 19769443, compound

HRID 1590040Notes

Reaction equation

HRID 1590040 reaction equation
[F:1][C:2]([F:8])([F:7])[C:3](OC)=[O:4].[NH2:9][N:10]1[CH2:16][CH:15]([O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)[C:14]2[CH:28]=[CH:29][CH:30]=[CH:31][C:13]=2[CH2:12][CH2:11]1>CO.C(N(CC)CC)C>[F:27][C:24]([F:25])([F:26])[C:21]1[CH:22]=[CH:23][C:18]([O:17][CH:15]2[C:14]3[CH:28]=[CH:29][CH:30]=[CH:31][C:13]=3[CH2:12][CH2:11][N:10]([NH:9][C:3](=[O:4])[C:2]([F:1])([F:7])[F:8])[CH2:16]2)=[CH:19][CH:20]=1

Participants

5

Reactant 2

HCID 9893Methyl trifluoroacetateHCID 19769424HCID 19769424, compound

Product 1

HCID 19769443HCID 19769443, compoundYield 78%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8471TriethylamineSolvent

Procedure

Methyl trifluoracetate (4.2 g) was added to a solution of 3-amino-2,3,4,5-tetrahydro-1-(4trifluoromethylphenoxy)-1H-3-benzazepine (8.4 g) in 100 mL anhydrous methanol and triethylamine (3.3 g). The solution was allowed to stand overnight at ambient temperature and thereafter concentrated. The residue was triturated with ether and the resultant product was collected and dried to yield 8.5 g white solid, mp 192°-195°.

Workup

  1. concentrationconcentrated
  2. customThe residue was triturated with ether
  3. customthe resultant product was collected
  4. customdried

Sources & evidence

ORD record
ord-b07bb840f0a94e2a94e8cf2619891037
Source dataset
uspto-grants-1993_04
Patent number
US05202319

Reaction notes

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