反应详情

The diester from Step 1 (13.0 g), K2CO3 (19.1 g), MeOH (120 mL), THF (80 mL) and H2O (80 mL) were stirred at room temperature for 2 days. The organic solvent was removed in vacuo, the residue poured onto H2O and extracted twice with EtOAc. The aqueous layer was acidified with 3N HCl and extracted with EtOAc (3×). This organic phase was then washed with brine, dried and evaporated to yield the title compound.

1. customThe organic solvent was removed in vacuo
2. additionthe residue poured onto H2O
3. extractionextracted twice with EtOAc
4. extractionextracted with EtOAc (3×)
5. washThis organic phase was then washed with brine
6. customdried
7. customevaporated