Potassium Carbonate → 1-Methyloctahydropyrrolo[3,4-B]pyrrole

HRID 1590132Notes

Reaction equation

HRID 1590132 reaction equation
[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2.C(=O)([O-])[O-].[K+].[K+]>Cl>[CH3:1][N:2]1[CH2:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 19100972HCID 19100972, compound

Product 1

HCID 150700011-Methyloctahydropyrrolo[3,4-B]pyrrole

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

9 g (45.4 mmol) of ethyl 2-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate together with 50 ml of concentrated hydrochloric acid are refluxed overnight. The batch is rendered alkaline using potassium carbonate and extracted ten times using 50 ml portions of chloroform, and the extracts are dried over potassium carbonate, concentrated and distilled.

Workup

  1. extractionextracted ten times
  2. dry with materialthe extracts are dried over potassium carbonate
  3. concentrationconcentrated
  4. distillationdistilled

Sources & evidence

ORD record
ord-45f9503bc3fc42a991a37eb0c12b5839
Source dataset
uspto-grants-1993_04
Patent number
US05202337

Reaction notes

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