Hydroxyamine hydrochloride → Ethyl 4-(hydroxyimino)-5-oxo-1-phenyl-3-pyrrolidineacetate

HRID 1590262Notes

Reaction equation

HRID 1590262 reaction equation
O=[C:2]1[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH:3]1[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16].Cl.[NH2:21][OH:22]>N1C=CC=CC=1>[OH:22][N:21]=[C:2]1[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH:3]1[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 57059855Ethyl 4,5-dioxo-1-phenyl-3-pyrrolidineacetate

Product 1

HCID 86746704Ethyl 4-(hydroxyimino)-5-oxo-1-phenyl-3-pyrrolidineacetate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of product of Example 62 in pyridine is treated with an excess of hydroxylamine hydrochloride and the reaction is stirred at room temperature for 2 d. The solution is concentrated in vacuo and the residue is chromatographed on silica gel to give the title compound.

Workup

  1. concentrationThe solution is concentrated in vacuo
  2. customthe residue is chromatographed on silica gel

Sources & evidence

ORD record
ord-94d20b50deb44793a86bc515156acfef
Source dataset
uspto-grants-1993_04
Patent number
US05202344

Reaction notes

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