Ammonium Acetate → HCID 86746719, compound

HRID 1590274Notes

Reaction equation

HRID 1590274 reaction equation
[C:1]([O-:4])(=[O:3])[CH3:2].[NH4+:5].[C:6]([O:10][C:11]([CH2:13][CH:14]([O:16][N:17]=[C:18]([C:21]#[N:22])[C:19]#[N:20])[CH3:15])=[O:12])([CH3:9])([CH3:8])[CH3:7]>CO>[C:1]([O-:4])(=[O:3])[CH3:2].[C:6]([O:10][C:11]([CH2:13][CH:14]([O:16][N:17]=[C:18]([C:19]#[N:20])[C:21]([NH2:5])=[NH2+:22])[CH3:15])=[O:12])([CH3:7])([CH3:8])[CH3:9]

Participants

4

Reactant 2

HCID 517165Ammonium AcetateHCID 19769258HCID 19769258, compound

Product 1

HCID 86746719HCID 86746719, compoundYield 59.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To ammonium acetate (18.5 g) dissolved in methanol (100 ml) was added 2-(tert-butoxycarbonylprop-2-oxyimino)malononitrile (19 g). After stirred for 2 hours, the mixture was standed overnight at room temperature. The reaction mixture was concentrated, and water (500 ml) was added therein. The obtained mixture was extracted with ethylacetate (500 ml). After the extract was dehydrated, filtered, and concentrated, ethylether was added therein, and stirred for 30 minutes. The precipitates were filtered to give the above-indicated compound (15 g) in pale yellow.

Workup

  1. waitthe mixture was standed overnight at room temperature
  2. concentrationThe reaction mixture was concentrated
  3. additionwater (500 ml) was added
  4. extractionThe obtained mixture was extracted with ethylacetate (500 ml)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. additionethylether was added
  8. stirringstirred for 30 minutes
  9. filtrationThe precipitates were filtered

Sources & evidence

ORD record
ord-d264d0acb4f1415fac32ff9cfc7507a4
Source dataset
uspto-grants-1993_04
Patent number
US05202315

Reaction notes

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