反应详情

温度

40 °C

To a solution of (2S,4R)-4-methanesulfonyloxy-2-(2-oxoimidazolidin-1-yl)carbonylpyrrolidine (14.9 g) in a mixture of methanol (150 ml) and tetrahydrofuran (150 ml) were added triethylamine (32.5 ml) and methyl iodide (11.4 ml) and the mixture was stirred at 40° C. for 2 hours. The reaction mixture was evaporated in vacuo. The resulting residue was chromatographed on silica gel (600 g) eluting with a mixture of chloroform and methanol (9:1 V/V). The fractions containing the desired compound were collected and evaporated in vacuo to give a residue. The residue was washed with dichloromethane (100 ml). The resulting precipitates were collected and dried in vacuo to give (2S,4R)-4-methanesulfonyloxy-1-methyl-2-(2-oxoimidazolidin-1-yl)carbonylpyrrolidine (2.30 g).

1. customThe reaction mixture was evaporated in vacuo
2. customThe resulting residue was chromatographed on silica gel (600 g)
3. washeluting with a mixture of chloroform and methanol (9:1 V/V)
4. additionThe fractions containing the desired compound
5. customwere collected
6. customevaporated in vacuo
7. customto give a residue
8. washThe residue was washed with dichloromethane (100 ml)
9. customThe resulting precipitates
10. customwere collected
11. customdried in vacuo