Methylamine → HCID 19767532, compound

HRID 1590552Notes

Reaction equation

HRID 1590552 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]2[O:6][CH:7]([CH2:10]Cl)[CH2:8][O:9][C:4]=2[CH:3]=1.[CH3:14][NH2:15]>>[Cl:1][C:2]1[CH:13]=[CH:12][C:5]2[O:6][CH:7]([CH2:10][NH:15][CH3:14])[CH2:8][O:9][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 233963HCID 233963, compound

Product 1

HCID 19767532HCID 19767532, compound

Procedure

14.8 g (0.0675 mol) of 6-chloro-2-chloromethylbenzo-1,4-dioxane and 31.0 g of methylamine are heated in a pressure tube for 24 hours at 120°. Evaporating off the excess methylamine and distilling under reduced pressure yield 6-chloro-2-methylaminomethylbenzo-1,4-dioxane having a boiling point of 70°-73° (at 0.001 mbar).

Workup

  1. customEvaporating off the excess methylamine
  2. distillationdistilling under reduced pressure

Sources & evidence

ORD record
ord-daa819d4eae342d3af1a0312fa989aff
Source dataset
uspto-grants-1993_04
Patent number
US05204334

Reaction notes

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