反应详情

To a solution of 7-hydroxyindan-1-one (6.0 g, 40 mmole) in trifluoroacetic acid (30 ml), triethylsilane (10.23 g, 87.9 mmole) was added. The mixture was refluxed for 5 hours, poured into water (200 ml) and extracted with diethyl ether (2×200 ml). The extract was washed with water. The ethereal solution was extracted with 4NNaOH (3×50 ml). The alkaline extract was washed with diethyl ether then acidified to pH1 with hydrochloric acid. The aqueous mixture was extracted with diethyl ether and the ethereal extract was washed with water and aqueous saturated sodium chloride, was dried, and the solvents evaporated to give 4-hydroxyindane as a colourless oil (4.9 g, 90%).

1. temperatureThe mixture was refluxed for 5 hours
2. extractionextracted with diethyl ether (2×200 ml)
3. washThe extract was washed with water
4. extractionThe ethereal solution was extracted with 4NNaOH (3×50 ml)
5. extractionThe alkaline extract
6. washwas washed with diethyl ether
7. extractionThe aqueous mixture was extracted with diethyl ether
8. extractionthe ethereal extract
9. washwas washed with water and aqueous saturated sodium chloride
10. customwas dried
11. customthe solvents evaporated