反应详情

A mixture of 18.8 g of 2-amino-5-methylpyridine and 27.8 g of p-bromophenacyl-bromide in 200 ml of acetone was refluxed for 8 hrs. The precipitate was collected and dissolved in hot methanol and 2 ml of concentrated HBr was added. The methanol solution was then basified with ammonium hydroxide. The precipitated product was collected and recrystallized from ethanol; yield 18.5 g (68%); mp 215°-216° C.

1. temperaturewas refluxed for 8 hrs
2. customThe precipitate was collected
3. dissolutiondissolved in hot methanol
4. addition2 ml of concentrated HBr was added
5. customThe precipitated product was collected
6. customrecrystallized from ethanol