Pyridine → 1,8-Diazabicyclo(5.4.0)undec-7-ene

HRID 1590635Notes

Reaction equation

HRID 1590635 reaction equation
ClC([O-])=O.[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C1COCC1>[CH2:8]1[CH2:9][CH2:10][N:5]2[C:10](=[N:5][CH2:6][CH2:7][CH2:8]2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 1049PyridineHCID 21226386Carbonochloridate

Product 1

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compounds of Formula (I) wherein R1 is --SO2NHCO2R23 may be prepared by reacting an appropriate chloroformate with the sulfonamide (9) in pyridine or in the presence of DBU in THF to afford the desired compound (10), as outlined in Scheme 2. ##STR15##

Workup

  1. custommay be prepared

Sources & evidence

ORD record
ord-a0e5cabcedbd4550bd180f1768da8f22
Source dataset
uspto-grants-1993_04
Patent number
US05204354

Reaction notes

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