Dimethylformamide → HCID 15753764, compound

HRID 1590661Notes

Reaction equation

HRID 1590661 reaction equation
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].CN(C)C=O.Cl[CH:16]([N:27]1[CH:31]=[N:30][CH:29]=[N:28]1)[CH:17]([O:19][C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)[CH3:18]>O>[C:1]1([S:7][CH:16]([N:27]2[CH:31]=[N:30][CH:29]=[N:28]2)[CH:17]([O:19][C:20]2[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=2)[CH3:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 7969ThiophenolHCID 24758Sodium hydrideHCID 15753763HCID 15753763, compound

Product 1

HCID 15753764HCID 15753764, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

13 q (0.12 mol of thiophenol were added slowly at 25° C. to a solution of 4.0 g of sodium hydride (80% strength by weight suspension in mineral oil) and 100 ml of N,N-dimethylformamide, followed, after stirring for 30 minutes, by 19.8 g (0.08 mol) of 1-chloro-1-(1,2,4-triazol-1-yl)-2-(4-methylphenoxy)-propane. After a reaction time of 24 hours at 25° C., 100 ml of water were added. Extraction with methyl tert-butyl ether was carried out, after which the organic phase was washed and was worked up in a conventional manner.

Workup

  1. extractionExtraction with methyl tert-butyl ether
  2. washafter which the organic phase was washed

Sources & evidence

ORD record
ord-fb49814758954cfc8a41c560f1125ef5
Source dataset
uspto-grants-1993_04
Patent number
US05204362

Reaction notes

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