Stearoyl chloride → HCID 22463279, compound

HRID 1590936Notes

Reaction equation

HRID 1590936 reaction equation
[C:1](Cl)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH:21]1([O:27][N:28]2[C:33]([CH3:35])([CH3:34])[CH2:32][CH:31]([OH:36])[CH2:30][C:29]2([CH3:38])[CH3:37])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[CH:21]1([O:27][N:28]2[C:29]([CH3:37])([CH3:38])[CH2:30][CH:31]([O:36][C:1](=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:32][C:33]2([CH3:35])[CH3:34])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 8212Stearoyl chlorideHCID 113228111-Cyclohexyloxy-2,2,6,6-tetramethyl-piperidin-4-ol

Product 1

HCID 22463279HCID 22463279, compoundYield 69%

Procedure

The title compound is prepared in 69% yield from the reaction of octadecanoyl chloride with 1-cyclohexyloxy-4-hydroxy-2,2,6,6-tetramethylpiperidine following the procedure in Example 17. Purification (Waters Prep. 500A HPLC, 100:1 heptane:ethyl acetate) yields a white solid, m.p. 44°-47° C.

Workup

  1. customPurification (Waters Prep. 500A HPLC, 100:1 heptane:ethyl acetate)
  2. customyields a white solid, m.p. 44°-47° C.

Sources & evidence

ORD record
ord-0692247164564da8baea12e7a7add959
Source dataset
uspto-grants-1993_04
Patent number
US05204473

Reaction notes

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