Hydrochloric Acid → BOC-Thr(Bzl)-Pro-OBzl

HRID 1590973Notes

Reaction equation

HRID 1590973 reaction equation
[NH:1]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[C@H:2]([C:13]([OH:15])=O)[C@@H:3]([CH3:12])[O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.Cl.[NH:24]1[CH2:38][CH2:37][CH2:36][C@H:25]1[C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27]>>[NH:1]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[C@H:2]([C:13]([N:24]1[CH2:38][CH2:37][CH2:36][C@H:25]1[C:26]([O:28][CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)=[O:27])=[O:15])[C@@H:3]([CH3:12])[O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 736155Benzyl L-prolinateHCID 1549483L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-

Product 1

HCID 15003996BOC-Thr(Bzl)-Pro-OBzlYield 95.3%

Procedure

By using 8.66 g of Boc-Thr(Bzl)-OH and 7.42 g of HCl.H-Pro-OBzl, and the same procedure as in Reference Example 15 was repeated to obtain 13.25 g (yield: 95.3%) of the above mentioned objective product.

Workup

  1. customto obtain 13.25 g (yield: 95.3%) of the

Sources & evidence

ORD record
ord-49144918cd224e7c8117353766aa5402
Source dataset
uspto-grants-1993_04
Patent number
US05204326

Reaction notes

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