反应详情

2-(4-(4-Chlorophenoxy)phenoxy)propionic acid chloride (0.6 g) and 4-(4-nitrophenoxy)phenol (0.5 g) were dissolved in dry tetrahydrofuran (10 ml), and the solution was stirred with an addition of triethylamine (0.3 ml) at room temperature for 2 hours. After completion of the reaction, the solvent was evaporated under a reduced pressure, the residue was dissolved in methylene chloride (20 ml), and washed with 1 N hydrochloric acid, water, saturated aqueous sodium hydrogen carbonate, water, saturated aqueous sodium hydrogen carbonate, water, and aqueous saturated sodium chloride. After drying over anhydrous magnesium sulfate, the solvent was evaporated and the residue obtained was purified by medium pressure column chromatography to obtain 4-(4-nitrophenoxy)phenyl 2-(4-(4-chlorophenoxy)phenoxy)propionate (0.8 g)

1. customAfter completion of the reaction
2. customthe solvent was evaporated under a reduced pressure
3. dissolutionthe residue was dissolved in methylene chloride (20 ml)
4. washwashed with 1 N hydrochloric acid, water, saturated aqueous sodium hydrogen carbonate, water, saturated aqueous sodium hydrogen carbonate, water, and aqueous saturated sodium chloride
5. dry with materialAfter drying over anhydrous magnesium sulfate
6. customthe solvent was evaporated
7. customthe residue obtained
8. customwas purified by medium pressure column chromatography