反应详情

5-(2,4-Dichlorophenoxy)-2-nitrophenol (0.8 g) and triethylamine (0.6 ml) were dissolved in dry tetrahydrofuran (10 ml), and the solution was stirred at room temperature for 2 hours, with an addition of a solution of 2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionic acid chloride (0.8 g), in dry tetrahydrofuran (10 ml). After completing the reaction, the solvent was distilled off under a reduced pressure and the residue was dissolved in methylene chloride (20 ml), followed by washing with 1 N hydrochloric acid, water, a saturated aqueous sodium bicarbonate solution, water, and a saturated aqueous sodium chloride solution. The resultant reaction mixture was dried over anhydrous magnesium sulfate, ether was evaporated under a reduced pressure, and the resultant residue was subjected to silica gel medium pressure column chromatography for purification. Thus, the title compound (0.9 g) was obtained in the form of a colorless oily product.

1. customthe reaction
2. distillationthe solvent was distilled off under a reduced pressure
3. dissolutionthe residue was dissolved in methylene chloride (20 ml)
4. washby washing with 1 N hydrochloric acid, water
5. customThe resultant reaction mixture
6. dry with materialwas dried over anhydrous magnesium sulfate, ether
7. customwas evaporated under a reduced pressure
8. customthe resultant residue was subjected to silica gel medium pressure column chromatography for purification