反应详情

15.3 parts of phosphoryl trichloride are added to a mixture of 14 parts of 2-amino-3-cyano-4-hydroxythiophene, 7.9 parts of pyridine and 70 parts of tetrahydrofuran, and the mixture is then heated at the boil for 1 hour. After cooling, the mixture is poured onto water and left to stand overnight, and the precipitate is filtered off under suction, washed with water and dried. 9.4 parts (60% of theory) of 2-amino-4-chloro-3-cyanothiophene are obtained.

1. temperaturethe mixture is then heated at the boil for 1 hour
2. temperatureAfter cooling
3. additionthe mixture is poured onto water
4. waitleft
5. filtrationthe precipitate is filtered off under suction
6. washwashed with water
7. customdried