Hydrochloric Acid → HCID 19766770, compound

HRID 1591297Notes

Reaction equation

HRID 1591297 reaction equation
CN(C)C=[N:4][C:5]1[S:6][C:7]([CH3:13])=[C:8]([Cl:12])[C:9]=1[C:10]#[N:11].Cl.C([O-])(=O)C.[Na+]>C(O)C>[NH2:4][C:5]1[S:6][C:7]([CH3:13])=[C:8]([Cl:12])[C:9]=1[C:10]#[N:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 517045Sodium AcetateHCID 54464853HCID 54464853, compound

Product 1

HCID 19766770HCID 19766770, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 6.1 parts of N,N-dimethyl-N'-(4-chloro-3-cyano-5-methylthien-2-yl)-formamidine, 50 parts of ethanol and 2 parts of concentrated hydrochloric acid is heated at the boil for 1 hour. Thereafter, the mixture is added to a dilute aqueous sodium acetate solution, and the precipitate is filtered off under suction and dried. 4 parts (86% of theory) of 2-amino-4-chloro-3-cyano-5-methylthiophene are obtained.

Workup

  1. temperatureis heated at the boil for 1 hour
  2. filtrationthe precipitate is filtered off under suction
  3. customdried

Sources & evidence

ORD record
ord-0f8225343cc045c7a921e4e7a22ebb2b
Source dataset
uspto-grants-1993_04
Patent number
US05206375

Reaction notes

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