Hydrochloric Acid → HCID 86746763, compound

HRID 1591299Notes

Reaction equation

HRID 1591299 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH:10]=[O:11])=[C:5](Cl)[C:6]=1[C:7]#[N:8].[S:12]([O-:15])([O-:14])=[O:13].[Na+:16].[Na+].Cl>O>[NH2:1][C:2]1[S:3][C:4]([CH:10]=[O:11])=[C:5]([S:12]([O-:15])(=[O:14])=[O:13])[C:6]=1[C:7]#[N:8].[Na+:16]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 24437Sodium SulfiteHCID 27376122-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile

Product 1

HCID 86746763HCID 86746763, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

93.3 parts of 2-amino-4-chloro-3-cyano-5-formylthiophene, 126 parts of sodium sulfite and 300 parts of water are heated at the boil for 2 hours, after which 200 parts of concentrated hydrochloric acid are added to the ice-cooled mixture, and the mixture is left to stand overnight. Thereafter, the mixture is filtered under suction, and the residue is washed with a little ice water and dried. 85 parts (67% of theory) of sodium 2-amino-3-cyano-5-formylthien-4-ylsulfonate are obtained.

Workup

  1. temperaturecooled mixture
  2. waitthe mixture is left
  3. filtrationThereafter, the mixture is filtered under suction
  4. washthe residue is washed with a little ice water
  5. customdried

Sources & evidence

ORD record
ord-bc2017fce8794a05899dc9c6425ebcd7
Source dataset
uspto-grants-1993_04
Patent number
US05206375

Reaction notes

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