反应详情

A mixture of 5-chlorosalicylic acid (5.0 g, 29.0 mmol), potassium carbonate (10.8 g, 78.1 mmol), acetonitrile (100 ml), and 2-bromoethylmethyl ether (6.8 ml, 72.3 mmol) was heated under reflux for 20 hours. The mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (50 ml). The solution was washed with aqueous sodium hydroxide solution (1 M, 2×50 ml), washed with water (50 ml), dried over sodium sulfate, and concentrated under reduced pressure to provide 5-chloro-2-(2-methoxyethoxy)benzoic acid 2-methoxyethyl ester (7.83 g, 93% yield).

1. temperaturewas heated
2. temperatureunder reflux for 20 hours
3. filtrationThe mixture was filtered
4. concentrationthe filtrate was concentrated under reduced pressure
5. dissolutionThe residue was dissolved in ethyl acetate (50 ml)
6. washThe solution was washed with aqueous sodium hydroxide solution (1 M, 2×50 ml)
7. washwashed with water (50 ml)
8. dry with materialdried over sodium sulfate
9. concentrationconcentrated under reduced pressure