反应详情

For two hours, a solution of 430 mg (1.17 mmol) of tert.-butyl 3-[(2,3-dichlorobenzenesulphonyl)methylamino]propionate and 2.0 ml of trifluoroacetic acid in 30 ml of tetrahydrofuran was stirred at room temperature and then evaporated to dryness. About 30 ml of water were added to the residue and the mixture was extracted three times with in each case 20 ml of ethyl acetate. The organic extracts were washed with saturated sodium chloride solution, dried over sodium sulphate and evaporated to dryness. The product obtained in this manner was reacted further without additional purification.

1. customevaporated to dryness
2. additionAbout 30 ml of water were added to the residue
3. extractionthe mixture was extracted three times with in each case 20 ml of ethyl acetate
4. washThe organic extracts were washed with saturated sodium chloride solution
5. dry with materialdried over sodium sulphate
6. customevaporated to dryness
7. customThe product obtained in this manner
8. customwas reacted further without additional purification