Hydrochloric Acid → HCID 67138330, compound

HRID 1591998Notes

Reaction equation

HRID 1591998 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]2[CH2:20][C:19](=[O:21])[N:18]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH3:32])[S:17]2(=[O:34])=[O:33])=[CH:11][CH:10]=1)(C)(C)C.[ClH:36]>CCOC(C)=O>[ClH:36].[NH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][N:16]2[S:17](=[O:33])(=[O:34])[N:18]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=3[O:31][CH3:32])[C:19](=[O:21])[CH2:20]2)=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67139930HCID 67139930, compound

Product 1

HCID 67138330HCID 67138330, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title A compound, {4-[5-(2,4-dimethoxy-benzyl)-1,1,4-trioxo-1,2,5-thiadiazolidin-2-ylmethyl]-benzyl}-carbamic acid t-butyl ester (400 mg, 0.79 mmol) is dissolved in EtOAc (20 mL) with gentle warming. The cooled solution is saturated with HCl gas and stirred for 30 min. The resulting precipitate is collected by filtration, washed with EtOAc and dried to give 5-(4-aminomethyl-benzyl)-2-(2,4-dimethoxy-benzyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one hydrochloride: [M+1]+=406.

Workup

  1. filtrationThe resulting precipitate is collected by filtration
  2. washwashed with EtOAc
  3. customdried

Sources & evidence

ORD record
ord-d92c20e7c1db42e3a57e35675205c217
Source dataset
uspto-grants-2007_11
Patent number
US07291635B2

Reaction notes

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