Hydrochloric Acid → HCID 11213457, compound

HRID 1592324Notes

Reaction equation

HRID 1592324 reaction equation
C(OC([N:8]([CH2:19][C@@H:20]1[CH2:25][CH2:24][CH2:23][CH2:22][C@H:21]1[NH:26][C:27]([NH:29][C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]2[N:40]([CH3:41])[N:39]=[N:38][N:37]=2)[CH:31]=1)=[O:28])[CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)=O)(C)(C)C.Cl>O1CCOCC1>[F:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:11][CH2:10][CH2:9][NH:8][CH2:19][C@@H:20]2[CH2:25][CH2:24][CH2:23][CH2:22][C@H:21]2[NH:26][C:27]([NH:29][C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([C:36]3[N:40]([CH3:41])[N:39]=[N:38][N:37]=3)[CH:31]=2)=[O:28])=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58997671HCID 58997671, compound

Product 1

HCID 11213457HCID 11213457, compoundYield 102.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product of Step j (90 mg) and 4N HCl in dioxane (50 mL) were mixed and stirred at room temperature for 3 hours. The reaction was stripped on the rotary evaporator and restripped twice from isopropanol on the rotary evaporator to yield 76 mg of a glass. MS (ESI) detects (M+H)+=466.3.

Workup

  1. customThe reaction was stripped on the rotary evaporator
  2. customrestripped twice from isopropanol on the rotary evaporator

Sources & evidence

ORD record
ord-95658183d1f34d5a99b188cf2b454c17
Source dataset
uspto-grants-2007_11
Patent number
US07291744B2

Reaction notes

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