Thiazole → HCID 69411283, compound

HRID 1592760Notes

Reaction equation

HRID 1592760 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.C([Li])CCC.[C:11]([N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH:30]=O)[CH2:20][CH2:19]1)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>>[C:11]([N:18]1[CH2:23][CH2:22][N:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH2:30][C:2]2[S:1][CH:5]=[CH:4][N:3]=2)[CH2:20][CH2:19]1)([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]

Participants

4

Reactant 3

HCID 9256ThiazoleHCID 64909901-Boc-4-(2-formylphenyl)piperazineHCID 178418339Butyllithium

Product 1

HCID 69411283HCID 69411283, compound

Procedure

Thiazole was lithiated with n-butyllithium and reacted with N-Boc-4-(2-formylphenyl)-piperazine in a manner similar to preparation 113A. The resulting alcohol was deoxygenated in a manner similar to preparation 115A to afford the final compound. LRMS (ESI+): 360.1 (M+1)

Workup

  1. customThe resulting alcohol was deoxygenated in a manner similar to preparation 115A

Sources & evidence

ORD record
ord-0e86953e25c04b138611cfa183107bce
Source dataset
uspto-grants-2007_11
Patent number
US07291619B2

Reaction notes

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