Hydrochloric Acid → HCID 69410555, compound

HRID 1592782Notes

Reaction equation

HRID 1592782 reaction equation
[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([CH2:6][CH:7]([NH:28][C:29](=[O:43])[CH2:30][C@@H:31]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH2:33][N:32]2[CH:40]([CH3:42])[CH3:41])[C:8](=[O:27])[N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[CH2:21][N:22]3[CH:26]=[N:25][CH:24]=[N:23]3)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[ClH:46]>>[ClH:1].[ClH:46].[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([CH2:6][CH:7]([NH:28][C:29](=[O:43])[CH2:30][C@@H:31]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH2:33][N:32]2[CH:40]([CH3:41])[CH3:42])[C:8](=[O:27])[N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[CH2:21][N:22]3[CH:26]=[N:25][CH:24]=[N:23]3)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 69410556HCID 69410556, compound

Product 1

HCID 69410555HCID 69410555, compound

Procedure

Into a flask containing (R)-N-{1-(4-chlorobenzyl)-2-oxo-2-[4-(2-([1,2,4]triazol-1-yl)methylphenyl)-piperazin-1-yl]-ethyl}-2-(2-isopropyl-2,3-dihydro-1H-isoindol-1-yl)-acetamide (Example 162) was added 1.0 N HCl (5 mL). After about an hour, the solution was solidified at −78° C., and the solid lyophilized to give about 0.06 g of the final compound as tan solids. ES MS 626.3 (M+H)

Workup

  1. waitAfter about an hour
  2. customwas solidified at −78° C.

Sources & evidence

ORD record
ord-1b762a1707264d7faa457683e697c4fc
Source dataset
uspto-grants-2007_11
Patent number
US07291619B2

Reaction notes

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