Hydrochloric Acid → HCID 69038784, compound

HRID 1592868Notes

Reaction equation

HRID 1592868 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]([CH2:20][CH2:21][NH2:22])([NH:12]C(OC(C)(C)C)=O)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[ClH:23].C(OCC)C>C(O)(C)C>[ClH:23].[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]([NH2:12])([CH2:20][CH2:21][NH2:22])[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 69037775HCID 69037775, compound

Product 1

HCID 69038784HCID 69038784, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

To a solution of 3.01 g (9.56 mmol) of 4-(2-amino-ethyl)-4-tert-butoxycarbonylamino-piperidine-1-carboxylic acid ethyl ester in 19 ml of isopropanol was added 8 ml of a solution of hydrochloric acid (5.6 N) in isopropanol and the resulting solution was stirred at room temperature for 3 h. The mixture was cooled and diethyl ether was added. The resulting precipitate was filtered. The product was dried to give 2.49 g of pure compound as a white solid.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationThe resulting precipitate was filtered
  3. customThe product was dried

Sources & evidence

ORD record
ord-85efd189b98a4ee891efc72279fde7d6
Source dataset
uspto-grants-2007_11
Patent number
US07294631B2

Reaction notes

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