Cyclopropanecarbonyl chloride → HCID 10455910, compound

HRID 1592902Notes

Reaction equation

HRID 1592902 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)=[N:10][N:11]([C:13]3[CH:14]=[CH:15][C:16]4[N:17]([CH:19]=[N:20][N:21]=4)[N:18]=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.[CH:29]1([C:32](Cl)=[O:33])[CH2:31][CH2:30]1>>[CH:29]1([C:32]([NH:1][C:2]2[CH:7]=[C:6]([C:8]3[C:9]([C:22]4[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=4)=[N:10][N:11]([C:13]4[CH:14]=[CH:15][C:16]5[N:17]([CH:19]=[N:20][N:21]=5)[N:18]=4)[CH:12]=3)[CH:5]=[CH:4][N:3]=2)=[O:33])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 9976519HCID 9976519, compound

Product 1

HCID 10455910HCID 10455910, compoundYield 37.3%

Procedure

The reaction was carried out in the same manner as in Example 9 except for using 200 mg (0.54 mmol) of 4-(2-aminopyridin-4-yl)-3-(4-fluorophenyl)-1-([1,2,4]triazolo-[4,3-b]pyridazin-6-yl)-1H-pyrazole obtained by the same reaction as in Example 8-2), and using 59.0 mg (0.56 mmol) of cyclopropylcarbonyl chloride in place of acetic anhydride to obtain 88.6 mg of the title compound as a white powder. (Yield: 37%)

Workup

  1. customobtained by the same reaction as in Example 8-2), and

Sources & evidence

ORD record
ord-763039fd68fc475282a2d487cf537dd7
Source dataset
uspto-grants-2007_11
Patent number
US07294625B2

Reaction notes

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