反应详情

温度

80 °C

2-Fluoro-4-methylphenylamine (0.259 g, 2.07 mmol), palladium (II) acetate (0.046 g, 0.205 mmol), rac-2,2-bis(diphenylphosphino)-1,1′-binaphthyl (0.192 g, 0.308 mmol), and cesium carbonate (1.00 g, 3.08 mmol) were added to a solution of 4-chloro-1,2,5-trimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester (0.50 g, 2.05 mmol) in toluene (7 mL) in a sealed vial. After stirring 10 minutes, the mixture was heated to 80° C. After 24 hours, the reaction mixture was cooled to room temperature and diluted with EtOAc. The resulting precipitate was filtered and washed with EtOAc. The filtrate was diluted with EtOAc and washed with water. The aqueous layer was reextracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4) and concentrated. Purification by flash column chromatography (20:1 methylene chloride/MeOH) gave 0.048 g (71%) desired product.

1. waitAfter 24 hours
2. temperaturethe reaction mixture was cooled to room temperature
3. filtrationThe resulting precipitate was filtered
4. washwashed with EtOAc
5. additionThe filtrate was diluted with EtOAc
6. washwashed with water
7. washThe combined organic layers were washed with brine
8. dry with materialdried (Na2SO4)
9. concentrationconcentrated
10. customPurification by flash column chromatography (20:1 methylene chloride/MeOH)