Methyl acetoacetate → 5-(3,5-Bis-trifluoromethyl-phenyl)-1-cyclopropylmethyl-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide

HRID 1593157노트

반응식

C[O:2][C:3](=O)[CH2:4][C:5](=O)[CH3:6].[F:9][C:10]([F:26])([F:25])[C:11]1[CH:12]=[C:13]([C:21](=O)[CH2:22]Br)[CH:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=1.[CH:27]1([CH2:30][NH2:31])[CH2:29][CH2:28]1.[CH:32]1([NH2:38])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1>>[CH:32]1([NH:38][C:3]([C:4]2[CH:22]=[C:21]([C:13]3[CH:12]=[C:11]([C:10]([F:26])([F:25])[F:9])[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=3)[N:31]([CH2:30][CH:27]3[CH2:29][CH2:28]3)[C:5]=2[CH3:6])=[O:2])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1

참가 물질

반응물 4

HCID 7757Methyl acetoacetate

HCID 7965Cyclohexylamine

HCID 75646Cyclopropanemethanamine

HCID 27361703,5-Bis(trifluoromethyl)phenacyl bromide

생성물 1

HCID 589989605-(3,5-Bis-trifluoromethyl-phenyl)-1-cyclopropylmethyl-2-methyl-1H-pyrrole-3-carboxylic acid cyclohexylamide

실험 절차

The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 1-(3,5-Bis-trifluoromethyl-phenyl)-2-bromo-ethanone as compound of formula S, cyclopropanemethylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 473.2 (M+H)+.

출처 및 근거

ORD 기록: ord-acde1041e37241d294901f8ede2cd138
출처 데이터셋: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07294644B2

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