反应详情

Methyl [4-(4-methoxy-2-nitrophenyl)aminosulfonyl-3,5-dimethylphenoxy]acetate (Intermediate A2, 8.1 g, 0.019 mol) in 200 mL ethyl acetate was stirred with Raney nickel (0.75 g) for 30 min and filtered through a celite pad with the aid of an additional 100 mL of ethyl acetate. The filtrate was mixed with platinum oxide (0.40 g, 0.0018 mol) and hydrogenated to give 7.8 g (100%) of the title compound.

1. filtrationfiltered through a celite pad with the aid of an additional 100 mL of ethyl acetate