HCID 69417111, compound → HCID 69418947, compound

HRID 1593250Notes

Reaction equation

HRID 1593250 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N+:24]([O-])=O)=[C:7]([NH:9][S:10]([C:13]2[CH:23]=[CH:22][C:16]([O:17][CH2:18][C:19]([NH2:21])=[O:20])=[CH:15][CH:14]=2)(=[O:12])=[O:11])[CH:8]=1.[H][H]>CN(C)C(=O)C.[Pt](=O)=O>[NH2:24][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][C:7]=1[NH:9][S:10]([C:13]1[CH:23]=[CH:22][C:16]([O:17][CH2:18][C:19]([NH2:21])=[O:20])=[CH:15][CH:14]=1)(=[O:12])=[O:11]

Participants

5

Reactant 2

HCID 69417111HCID 69417111, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 69418947HCID 69418947, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 31374DimethylacetamideSolvent

Procedure

2-(4-{[(5-methoxy-2-nitrophenyl)amino]sulfonyl}phenoxy)acetamide (Intermediate A60, 2.0 g, 0.0052 mol) was hydrogenated in N,N-dimethylacetamide with platinum(IV)oxide catalyst (0.2 g) until hydrogen uptake ceased. The catalyst was removed by filtration and the resulting mixture was concentrated under reduced pressure. The resulting solid was triturated with ethyl acetate to give 1.7 g (93%) of the title compound, “amine sulfonamide”.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe resulting mixture was concentrated under reduced pressure
  3. customThe resulting solid was triturated with ethyl acetate

Sources & evidence

ORD record
ord-80e089228f184afab24e850195ab32a4
Source dataset
uspto-grants-2007_11
Patent number
US07294716B2

Reaction notes

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