Hydrochloric Acid → 2-Cyclopropylquinazoline-6-carboxylic acid

HRID 1593385Notes

Reaction equation

HRID 1593385 reaction equation
C[CH:2]([OH:4])[CH3:3].[CH:5]1([C:8]2[N:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=C(C#N)[CH:14]=3)[N:9]=2)[CH2:7][CH2:6]1.[OH-:20].[K+].Cl>O>[CH:5]1([C:8]2[N:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:3]([C:2]([OH:4])=[O:20])[CH:14]=3)[N:9]=2)[CH2:7][CH2:6]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 14797Potassium HydroxideHCID 230820422-Cyclopropylquinazoline-6-carbonitrile

Product 1

HCID 686962702-Cyclopropylquinazoline-6-carboxylic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into 8 ml of 2-propanol and 1 ml of water were dissolved 210 mg of 2-cyclopropylquinazoline-6-carbonitrile and 450 mg of potassium hydroxide, followed by heating under refluxing overnight. Hydrochloric acid was added thereto and the solvent was removed by evaporation to obtain the title compound as a crude carboxylic acid.

Workup

  1. temperatureby heating
  2. temperatureunder refluxing overnight
  3. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-bc5bbe1747a94d5eb61ba7ee5ccd0dc9
Source dataset
uspto-grants-2007_11
Patent number
US07297698B2

Reaction notes

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