4-Pyridinecarboxaldehyde → 4-{4-[3-(1-Methoxyiminoindan-5-yl)4-oxo-4-pyridin-4-ylbutanoyl]phenoxy}piperidine-1-carboxylic acid tert-butyl ester

HRID 1593439Notes

Reaction equation

HRID 1593439 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:36])/[CH:22]=[CH:23]/[C:24]3[CH:25]=[C:26]4[C:30](=[CH:31][CH:32]=3)[C:29](=[N:33][O:34][CH3:35])[CH2:28][CH2:27]4)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[N:37]1[CH:42]=[CH:41][C:40]([CH:43]=[O:44])=[CH:39][CH:38]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:36])[CH2:22][CH:23]([C:24]3[CH:25]=[C:26]4[C:30](=[CH:31][CH:32]=3)[C:29](=[N:33][O:34][CH3:35])[CH2:28][CH2:27]4)[C:43](=[O:44])[C:40]3[CH:41]=[CH:42][N:37]=[CH:38][CH:39]=3)=[CH:17][CH:16]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 865954184-{4-[(E)-3-(1-Methoxyimino-indan-5-yl)allanoyl]phenoxy}piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 865954194-{4-[3-(1-Methoxyiminoindan-5-yl)4-oxo-4-pyridin-4-ylbutanoyl]phenoxy}piperidine-1-carboxylic acid tert-butyl esterYield 88%

Procedure

The title compound (0.9 g, 88%) was prepared from the product of Step 2 and pyridine-4-carboxaldehyde using the method of Example 1 Step 4; MS(ES+) m/e 597 [M+H]+.

Sources & evidence

ORD record
ord-b3c2850a2cef4b099efa1e0e0a8b550e
Source dataset
uspto-grants-2007_11
Patent number
US07297694B2

Reaction notes

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