反应详情

A solution of 10.0 g (47.8 mmol) of 8-bromo-1-octanol, 10.41 g (120 mmol) of morpholine and tetrahydrofuran was heated to reflux for 3 hr. The cooled reaction mixture was treated with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The organic phase was washed with brine, dried over magnesium sulfate and concentrated to give 10.50 g of 4-(8-hydroxyoctyl)morpholine.

1. temperatureto reflux for 3 hr
2. customThe cooled reaction mixture
3. extractionextracted with ethyl acetate
4. washThe organic phase was washed with brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated