Phosphorus oxychloride → HCID 11113759, compound

HRID 1593947Notes

Reaction equation

HRID 1593947 reaction equation
[N:1]1([CH2:6][CH2:7][C:8]([NH:10][C:11]2[CH:24]=[CH:23][C:22]3[NH:21][C:20]4[C:15](=[CH:16][C:17]([NH:25][C:26](=[O:34])[CH2:27][CH2:28][N:29]5[CH2:33][CH2:32][CH2:31][CH2:30]5)=[CH:18][CH:19]=4)[C:14](=O)[C:13]=3[CH:12]=2)=[O:9])[CH2:5][CH2:4][CH2:3][CH2:2]1.O=P(Cl)(Cl)[Cl:38]>C(OCC)C>[Cl:38][C:14]1[C:15]2[C:20]([N:21]=[C:22]3[C:13]=1[CH:12]=[C:11]([NH:10][C:8](=[O:9])[CH2:7][CH2:6][N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)[CH:24]=[CH:23]3)=[CH:19][CH:18]=[C:17]([NH:25][C:26](=[O:34])[CH2:27][CH2:28][N:29]1[CH2:33][CH2:32][CH2:31][CH2:30]1)[CH:16]=2

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 21074078HCID 21074078, compound

Product 1

HCID 11113759HCID 11113759, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2,7-Bisamidoacridone BR-ACO-16 (1 g, 2.1 mmol) was treated with refluxing POCl3 for 3 hr. The reaction was cooled, and anhydrous diethyl ether was added to precipitate product. Solids were filtered from solution to give the desired product JM-ACI-43 (750 mg, 72%) as a yellow solid.

Workup

  1. temperatureThe reaction was cooled
  2. customto precipitate product
  3. filtrationSolids were filtered from solution

Sources & evidence

ORD record
ord-c012d35df7824ee5af2938643a6c096b
Source dataset
uspto-grants-2007_11
Patent number
US07300930B2

Reaction notes

Loading…