Hydrochloric Acid → HCID 62480333, compound

HRID 1594002Notes

Reaction equation

HRID 1594002 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.Br[C:9]1[S:10][CH:11]=[CH:12][N:13]=1.Cl>>[CH3:1][CH:2]1[NH:3][CH2:4][CH2:5][N:6]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)[CH2:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 660572-MethylpiperazineHCID 764302-Bromothiazole

Product 1

HCID 62480333HCID 62480333, compoundYield 90.2%

Procedure

30.06 g (300.0 mmol) of 2-methylpiperazine were combined with 4.51 ml (50.0 mmol) of 2-bromothiazole. This mixture was fused and refluxed 5 min. The reaction mixture was cooled and taken up in 10% strength hydrochloric acid and washed with EA. The aqueous phase was set to pH>12 with a 10% strength aq. NaOH solution and then extracted with EA. The organic phase was dried over MgSO4 and conc. in vacuo. There were obtained 8.26 g (45.1 mmol, 90%) of 3-methyl-1-thiazol-2-ylpiperazine.

Workup

  1. temperaturerefluxed 5 min
  2. temperatureThe reaction mixture was cooled
  3. washwashed with EA
  4. extractionextracted with EA
  5. dry with materialThe organic phase was dried over MgSO4 and conc. in vacuo

Sources & evidence

ORD record
ord-7d1e0e53bed2463cb28340dc70e0db85
Source dataset
uspto-grants-2007_11
Patent number
US07300939B2

Reaction notes

Loading…